CALL FOR PAPERS Renal Hemodynamics: Integrating With the Nephron and Beyond Effects of NKCC2 isoform regulation on NaCl transport in thick ascending limb and macula densa: a modeling study
نویسندگان
چکیده
Aurélie Edwards, Hayo Castrop, Kamel Laghmani, Volker Vallon, and Anita T. Layton University of Paris 6, University of Paris 5, Institut National de la Santé et de la Recherche Médicale UMRS 1138, Centre National de la Recherche Scientifique ERL 8228, Centre de Recherche des Cordeliers, Paris, France; Institute of Physiology University of Regensburg, Regensburg, Germany; Departments of Medicine and Pharmacology, University of California, San Diego, La Jolla, California, and San Diego Veterans Affairs Healthcare System, San Diego, California; and Department of Mathematics, Duke University, Durham, North Carolina
منابع مشابه
Effects of NKCC2 isoform regulation on NaCl transport in thick ascending limb and macula densa: a modeling study.
This study aims to understand the extent to which modulation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 differential splicing affects NaCl delivery to the macula densa. NaCl absorption by the thick ascending limb and macula densa cells is mediated by apical NKCC2. A recent study has indicated that differential splicing of NKCC2 is modulated by dietary salt (Schieβl IM, Rosenauer A, Kattler V,...
متن کاملPhysiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2).
The Na-K-2Cl cotransporter (NKCC2; BSC1) is located in the apical membrane of the epithelial cells of the thick ascending limb of the loop of Henle (TAL). NKCC2 facilitates ∼20-25% of the reuptake of the total filtered NaCl load. NKCC2 is therefore one of the transport proteins with the highest overall reabsorptive capacity in the kidney. Consequently, even subtle changes in NKCC2 transport act...
متن کاملRapid Publication Expression of the Na-K-2Cl Cotransporter by Macula Densa and Thick Ascending Limb Cells of Rat and Rabbit Nephron
Sodium and chloride transport by the macula densa and thick ascending limb of Henle’s loop participates importantly in extracellular fluid volume homeostasis, urinary concentration and dilution, control of glomerular filtration, and control of renal hemodynamics. Transepithelial Na and Cl transport across the apical membrane of thick ascending limb (TALH) cells is mediated predominantly by a lo...
متن کاملExpression of the Na-K-2Cl cotransporter by macula densa and thick ascending limb cells of rat and rabbit nephron.
Sodium and chloride transport by the macula densa and thick ascending limb of Henle's loop participates importantly in extracellular fluid volume homeostasis, urinary concentration and dilution, control of glomerular filtration, and control of renal hemodynamics. Transepithelial Na and Cl transport across the apical membrane of thick ascending limb (TALH) cells is mediated predominantly by a lo...
متن کاملCALL FOR PAPERS Mathematical Modeling of Renal Function Transport efficiency and workload distribution in a mathematical model of the thick ascending limb
Nieves-González A, Clausen C, Layton AT, Layton HE, Moore LC. Transport efficiency and workload distribution in a mathematical model of the thick ascending limb. Am J Physiol Renal Physiol 304: F653–F664, 2013. First published October 24, 2012; doi:10.1152/ajprenal.00101.2012.—The thick ascending limb (TAL) is a major NaCl reabsorbing site in the nephron. Efficient reabsorption along that segme...
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